在技术输出之前的时点适用

[出版论文]

“A population pharmacokinetic-pharmacodynamic model of YH12852, a highly selective 5-hydroxytryptamine 4 receptor agonist, in healthy subjects and patients with functional constipation”
(Kim et al. 2021. CPT Pharmacometrics Syst Pharmacol. 10:902-913)

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[出版论文]

"YH12852, a Potent and Selective Receptor Agonist of 5-hydroxytryptamine, Increased Gastrointestinal Motility in Healthy Volunteers and Patients With Functional Constipation"
(Lee et al., 2020. Clin Transl Sci. 0, 1–10)

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[出版论文]

"The novel, potent and highly selective 5-HT4 receptor agonist YH12852 significantly improves both upper and lower gastrointestinal motility"
(Jeong et al., 2017. Br J Pharmacol. 175(3):485 500)

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[出版论文]

"YH12852, a potent and highly selective 5-HT4 receptor agonist, significantly improves both upper and lower gastrointestinal motility in a guinea pig model of postoperative ileus"
(Hussain et al., 2017. Neurogastroenterol Motil. 29(10):1 6)

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[学会发表]

"A Population Pharmacokinetic-Pharmacodynamic Model to Characterize the Increase in Gastrointestinal Motility by YH12852, a Highly Selective 5-HT4 Receptor Agonist, in Healthy Subjects and Patients with Functional Constipation"
发表海报 (2019 AAPS)

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[学会发表]

"YH12852, a Novel and Highly Selective 5-hydroxytryptamine 4 Receptor Agonist, Increases Stool Frequency in Healthy Volunteers and Patients with Functional Constipation: A Randomized Double-blind Placebo/active-controlled Phase 1/2a Trial"
发表海报 (2017 UEGW)

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[学会发表]

"YH12852, a novel, potent and highly selective 5-HT4 agonist, improves delayed gastric emptying and restores feeding inhibition induced by acute restraint stress in rats"
发表海报 (2016 FNM)

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[学会发表]

"YH12852, a novel, potent and highly selective 5-HT4 receptor agonist, accelerates gastric emptying and small intestinal motility in guinea pigs and monkeys"
发表海报 (2016 DDW)

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[学会发表]

"YH12852, a novel and highly selective 5-HT4 receptor agonist, has a more potent and faster prokinetic effect on lower GI motility than prucalopride in healthy subjects"
演讲 (2016 DDW)

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[学会发表]

"A novel, potent and highly selective 5-HT4 receptor agonist, YH12852 significantly improves both upper and lower gastrointestinal motility in a guinea pig model of postoperative ileus"
发表海报 (2015 DDW)

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[学会发表]

"The Effects of YH12852 on the experimental model of postoperative ileus in guinea pig"
发表海报 (2015 ANMA)

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[学会发表]

"YH12852, a novel, potent and highly selective 5-HT4 agonist, improves delayed gastric emptying and restores feeding inhibition induced by acute restraint stress in rats"
发表海报 (2015 NeuroGASTRO)

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